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KMID : 0379520070230030245
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한국독성학회지
2007 Volume.23 No. 3 p.245 ~ p.251
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Genotoxicity Study of Water Extract of Cordyceps militaris Grown Upon Protuetja dreujtarsis
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Jo Wol-Soon
Nam Byung-Hyouk
Choi Yoo-Jin
Oh Su-Jung
Kang Eun-Young
Lee Sang-Ho
Jeong Min-Ho
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Abstract
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Water extract of Cordyceps militaris grown upon Protuetja dreujtarsis (CMPD) was examined for the genetic toxicity-bacterial mutagenicity, chromosome aberration, and micronucleus formation. For mutagenicity assay, bacterial reversion test with Salmonella typhimurium TA98, TA100, TA1535, TA 1537, and E. coli WP2uvrA were performed. The extract at the concentrations of 50~5,000 ㎍/plate did not induce mutagenicity at all. Chromosome aberration test was performed by using Chinese lung (CHL) cells. There was no significant chromosome aberration in CHL cells with S-9 mixture at the concentrations of 312.5~1,250 ㎍/㎖ of the extract and without S-9 mixture at the concentrations of 1.2~19.5 ㎍/㎖ of the extract. For micronucleus test, ICR mice were treated with the extract at the dose of 0.5, 1, and 2 g/㎏. The frequencies of the micronucleated polychromatic erythrocytes (MNPCE) in bone marrow preparations of the extract-treated group were not increased compared to the untreated control group. Taken together, our results show that water extract of CMPD did not induce any harmful genotoxicity.
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KEYWORD
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Cordyceps militaris extract, Protuetja dreujtarsis, Mutagenicity of Salmonella, Chromosome aberration, Micronucleated polychromatic erythrocytes (MNPCE)
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